The Science Behind Fucoidan

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Fucoidan is a bio-active component of Undaria Pinnatifida (Wakame) and other brown sea vegetables. It is one of the most heavily studied of natural bio-active substances in the world. There are over 100 peer reviewed and published scientific studies that use Fucoidan as a subject. Many are looking at it as a promising anti cancer drug while others are focused on its effects on skin, intestinal tract and as an absorber of heavy metals and radiation. There are compelling studies that look at its ability to act as a effective antiviral and antibacterial agent. Others look at its role as a powerful antioxidant.   Here are a small sample of these studies. More information about these and other studies can be found at PubMed, a database of scientific studies maintained by the US National Library of Medicine and the National Institutes of Health.

Anti Cancer Properties

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway.

Yang L, Wang P, Wang H, Li Q, Teng H, Liu Z, Yang W, Hou L, Zou X.

Mar Drugs. 2013 Jun 10;11(6):1961-76. doi: 10.3390/md11061961.

PMID:23752353[PubMed – in process] Free ArticleRelated citations

Select item 237378422.Fucoidan inhibits the growth of hepatocellular carcinoma independent of angiogenesis.

Zhu C, Cao R, Zhang SX, Man YN, Wu XZ.

Evid Based Complement Alternat Med. 2013;2013:692549. doi: 10.1155/2013/692549. Epub 2013 May 12.

PMID:23737842[PubMed – in process] Free PMC ArticleRelated citations

Select item 237036153.Major vault protein regulates class A scavenger receptor-mediated TNF-α synthesis and apoptosisin macrophages.

Ben J, Zhang Y, Zhou R, Zhang H, Zhu X, Li X, Zhang H, Li N, Zhou X, Bai H, Yang Q, Li D, Xu Y, Chen Q.

J Biol Chem. 2013 May 23. [Epub ahead of print]

PMID:23703615[PubMed – as supplied by publisher] Free ArticleRelated citations

Select item 235306464.Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/β-catenin signaling.

Xue M, Ge Y, Zhang J, Liu Y, Wang Q, Hou L, Zheng Z.

Nutr Cancer. 2013;65(3):460-8. doi: 10.1080/01635581.2013.757628.

PMID:23530646[PubMed – in process] Related citations

Select item 234185395.Low molecular weight fucoidan against renal ischemia-reperfusion injury via inhibition of the MAPK signaling pathway.

Chen J, Wang W, Zhang Q, Li F, Lei T, Luo D, Zhou H, Yang B.

PLoS One. 2013;8(2):e56224. doi: 10.1371/journal.pone.0056224. Epub 2013 Feb 13.

PMID:23418539[PubMed – in process] Free PMC ArticleRelated citations

Select item 233919036.Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells.

Zhang Z, Teruya K, Eto H, Shirahata S.

Biosci Biotechnol Biochem. 2013;77(2):235-42. Epub 2013 Feb 7.

PMID:23391903[PubMed – in process] Free ArticleRelated citations

Select item 233372537.The effect of sulfated (1→3)-α-l-fucan from the brown alga Saccharina cichorioides Miyabe on resveratrol-induced apoptosis in colon carcinoma Cells.

Vishchuk OS, Ermakova SP, Zvyagintseva TN.

Mar Drugs. 2013 Jan 21;11(1):194-212. doi: 10.3390/md11010194.

PMID:23337253[PubMed – in process] Free PMC ArticleRelated citations

Select item 233033028.Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells.

Zhang Z, Teruya K, Yoshida T, Eto H, Shirahata S.

Mar Drugs. 2013 Jan 9;11(1):81-98. doi: 10.3390/md11010081.

PMID:23303302[PubMed – in process] Free PMC ArticleRelated citations

Select item 231416849.Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation.

Alsac JM, Delbosc S, Rouer M, Journé C, Louedec L, Meilhac O, Michel JB.

J Vasc Surg. 2013 Mar;57(3):796-805. doi: 10.1016/j.jvs.2012.07.039. Epub 2012 Nov 8.

PMID:23141684[PubMed – indexed for MEDLINE] Related citations

Select item 2291627010.Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo.

Xue M, Ge Y, Zhang J, Wang Q, Hou L, Liu Y, Sun L, Li Q.

PLoS One. 2012;7(8):e43483. doi: 10.1371/journal.pone.0043483. Epub 2012 Aug 20.

PMID:22916270[PubMed – indexed for MEDLINE] Free PMC ArticleRelated citations

Select item 2287082011.Protective effect of fucoidan against acetaminophen-induced liver injury.

Hong SW, Lee HS, Jung KH, Lee H, Hong SS.

Arch Pharm Res. 2012 Jun;35(6):1099-105. doi: 10.1007/s12272-012-0618-5. Epub 2012 Jun 30.

PMID:22870820[PubMed – indexed for MEDLINE] Related citations

Select item 2279094012.Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation.

Yamasaki Y, Yamasaki M, Tachibana H, Yamada K.

Biosci Biotechnol Biochem. 2012;76(6):1163-8. Epub 2012 Jun 7.

PMID:22790940[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 2251049213.Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells.

Liu F, Wang J, Chang AK, Liu B, Yang L, Li Q, Wang P, Zou X.

Phytomedicine. 2012 Jun 15;19(8-9):797-803. doi: 10.1016/j.phymed.2012.03.015. Epub 2012 Apr 15.

PMID:22510492[PubMed – indexed for MEDLINE] Related citations

Select item 2236324214.Fucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitro.

Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer AS.

Mar Drugs. 2011 Dec;9(12):2605-21. doi: 10.3390/md9122605. Epub 2011 Dec 13.

PMID:22363242[PubMed – indexed for MEDLINE] Free PMC ArticleRelated citations

Select item 2232680915.Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells.

Jeong BE, Ko EJ, Joo HG.

Food Chem Toxicol. 2012 May;50(5):1480-4. doi: 10.1016/j.fct.2012.01.034. Epub 2012 Feb 1.

PMID:22326809[PubMed – indexed for MEDLINE] Related citations

Select item 2230116016.Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats.

Gao Y, Li C, Yin J, Shen J, Wang H, Wu Y, Jin H.

Environ Toxicol Pharmacol. 2012 Mar;33(2):304-11. doi: 10.1016/j.etap.2011.12.022. Epub 2011 Dec 27.

PMID:22301160[PubMed – indexed for MEDLINE] Related citations

Select item 2222244017.Neuroprotective effect of fucoidan on H2O2-induced apoptosis in PC12 cells via activation of PI3K/Akt pathway.

Gao Y, Dong C, Yin J, Shen J, Tian J, Li C.

Cell Mol Neurobiol. 2012 May;32(4):523-9. doi: 10.1007/s10571-011-9792-0. Epub 2012 Jan 6.

PMID:22222440[PubMed – indexed for MEDLINE] Related citations

Select item 2209657218.Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways.

Zhang Z, Teruya K, Eto H, Shirahata S.

PLoS One. 2011;6(11):e27441. doi: 10.1371/journal.pone.0027441. Epub 2011 Nov 11.

PMID:22096572[PubMed – indexed for MEDLINE] Free PMC ArticleRelated citations

Select item 2187503419.An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro.

Foley SA, Szegezdi E, Mulloy B, Samali A, Tuohy MG.

J Nat Prod. 2011 Sep 23;74(9):1851-61. doi: 10.1021/np200124m. Epub 2011 Aug 29. Erratum in: J Nat Prod. 2012 Sep 28;75(9):1674. Szegezdi, Eva [added]; Samali, Afshin [added].

PMID:21875034[PubMed – indexed for MEDLINE] Related citations

Select item 2187423020.Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages.

Takeda K, Tomimori K, Kimura R, Ishikawa C, Nowling TK, Mori N.

Int J Oncol. 2012 Jan;40(1):251-60. doi: 10.3892/ijo.2011.1168. Epub 2011 Aug 18.

PMID:21874230[PubMed – indexed for MEDLINE] Related citations

Skin Health

Novel hydrocolloid-sheet as wound dressing to stimulate healing-impaired wound healing in diabetic db/db mice.

Yanagibayashi S, Kishimoto S, Ishihara M, Murakami K, Aoki H, Takikawa M, Fujita M, Sekido M, Kiyosawa T.

Biomed Mater Eng. 2012;22(5):301-10. doi: 10.3233/BME-2012-0720.

PMID:23023147[PubMed – indexed for MEDLINE] Related citations

Select item 224310033.Topical application of fucoidan improves atopic dermatitis symptoms in NC/Nga mice.

Yang JH.

Phytother Res. 2012 Dec;26(12):1898-903. doi: 10.1002/ptr.4658. Epub 2012 Mar 19.

PMID:22431003[PubMed – indexed for MEDLINE] Related citations

Select item 223632424.Fucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitro.

Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer AS.

Mar Drugs. 2011 Dec;9(12):2605-21. doi: 10.3390/md9122605. Epub 2011 Dec 13.

PMID:22363242[PubMed – indexed for MEDLINE] Free PMC ArticleRelated citations

Select item 216411155.Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model.

Benlier E, Eskiocak S, Puyan FO, Kandulu H, Unal Y, Top H, Aygit AC.

Burns. 2011 Nov;37(7):1216-21. doi: 10.1016/j.burns.2011.04.008.

PMID:21641115[PubMed – indexed for MEDLINE] Related citations

Select item 216243966.Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo.

Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer AS.

Int J Biol Macromol. 2011 Oct 1;49(3):331-6. doi: 10.1016/j.ijbiomac.2011.05.009. Epub 2011 May 23.

PMID:21624396[PubMed – indexed for MEDLINE] Related citations

Select item 207317997.Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed of chitin/chitosan, fucoidan, and alginate as wound dressings.

Murakami K, Ishihara M, Aoki H, Nakamura S, Nakamura S, Yanagibayashi S, Takikawa M, Kishimoto S, Yokoe H, Kiyosawa T, Sato Y.

Wound Repair Regen. 2010 Sep-Oct;18(5):478-85. doi: 10.1111/j.1524-475X.2010.00606.x. Epub 2010 Aug 19.

PMID:20731799[PubMed – indexed for MEDLINE] Related citations

Select item 198071148.Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein.

Moon HJ, Park KS, Ku MJ, Lee MS, Jeong SH, Imbs TI, Zvyagintseva TN, Ermakova SP, Lee YH.

J Nat Prod. 2009 Oct;72(10):1731-4. doi: 10.1021/np800797v.

PMID:19807114[PubMed – indexed for MEDLINE] Related citations

Select item 197872749.Fucoidan-Vitamin C complex suppresses tumor invasion through the basement membrane, with scarce injuries to normal or tumor cells, via decreases in oxidative stress and matrix metalloproteinases.

Saitoh Y, Nagai Y, Miwa N.

Int J Oncol. 2009 Nov;35(5):1183-9.

PMID:19787274[PubMed – indexed for MEDLINE] Related citations

Select item 1977574810.Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings.

Murakami K, Aoki H, Nakamura S, Nakamura S, Takikawa M, Hanzawa M, Kishimoto S, Hattori H, Tanaka Y, Kiyosawa T, Sato Y, Ishihara M.

Biomaterials. 2010 Jan;31(1):83-90. doi: 10.1016/j.biomaterials.2009.09.031. Epub 2009 Sep 22.

PMID:19775748[PubMed – indexed for MEDLINE] Related citations

Select item 1912908311.Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts.

Moon HJ, Lee SH, Ku MJ, Yu BC, Jeon MJ, Jeong SH, Stonik VA, Zvyagintseva TN, Ermakova SP, Lee YH.

Eur J Dermatol. 2009 Mar-Apr;19(2):129-34. doi: 10.1684/ejd.2008.0611. Epub 2009 Jan 7.

PMID:19129083[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1904322112.Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits.

Sezer AD, Cevher E, Hatipoğlu F, Oğurtan Z, Baş AL, Akbuğa J.

Biol Pharm Bull. 2008 Dec;31(12):2326-33.

PMID:19043221[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1830214113.Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells.

Lee NY, Ermakova SP, Choi HK, Kusaykin MI, Shevchenko NM, Zvyagintseva TN, Choi HS.

Mol Carcinog. 2008 Aug;47(8):629-37. doi: 10.1002/mc.20428.

PMID:18302141[PubMed – indexed for MEDLINE] Related citations

Select item 1823928814.Fucoidan inhibits UVB-induced MMP-1 expression in human skin fibroblasts.

Moon HJ, Lee SR, Shim SN, Jeong SH, Stonik VA, Rasskazov VA, Zvyagintseva T, Lee YH.

Biol Pharm Bull. 2008 Feb;31(2):284-9.

PMID:18239288[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1820387215.Crucial role of neutrophils in the development of mechanical inflammatory hypernociception.

Cunha TM, Verri WA Jr, Schivo IR, Napimoga MH, Parada CA, Poole S, Teixeira MM, Ferreira SH, Cunha FQ.

J Leukoc Biol. 2008 Apr;83(4):824-32. doi: 10.1189/jlb.0907654. Epub 2008 Jan 18.

PMID:18203872[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1725776816.5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue.

Oliveira MC, Pelegrini-da-Silva A, Parada CA, Tambeli CH.

Neuroscience. 2007 Mar 16;145(2):708-14. Epub 2007 Jan 25.

PMID:17257768[PubMed – indexed for MEDLINE] Related citations

Select item 1636423417.Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis.

Senni K, Gueniche F, Foucault-Bertaud A, Igondjo-Tchen S, Fioretti F, Colliec-Jouault S, Durand P, Guezennec J, Godeau G, Letourneur D.

Arch Biochem Biophys. 2006 Jan 1;445(1):56-64. Epub 2005 Nov 28.

PMID:16364234[PubMed – indexed for MEDLINE] Related citations

Select item 1512365618.Characterization of sugar binding by osteoclast inhibitory lectin.

Gange CT, Quinn JM, Zhou H, Kartsogiannis V, Gillespie MT, Ng KW.

J Biol Chem. 2004 Jul 9;279(28):29043-9. Epub 2004 May 3.

PMID:15123656[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1502197419.Heparin protects against skin flap necrosis: relationship to neutrophil recruitment and anti-coagulant activity.

Törkvist L, Löfberg R, Raud J, Thorlacius H.

Inflamm Res. 2004 Jan;53(1):1-3. Epub 2004 Jan 1.

PMID:15021974[PubMed – indexed for MEDLINE] Related citations

Select item 1475805020.Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair.

O’Leary R, Rerek M, Wood EJ.

Biol Pharm Bull. 2004 Feb;27(2):266-70.

PMID:14758050[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Gastro Intestinal Tract

Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers.

Yu SH, Tang DW, Hsieh HY, Wu WS, Lin BX, Chuang EY, Sung HW, Mi FL.

Acta Biomater. 2013 Jul;9(7):7449-59. doi: 10.1016/j.actbio.2013.04.009. Epub 2013 Apr 11.

PMID:23583645[PubMed – in process] Related citations

Select item 235421152.The effects of liquid versus spray-dried Laminaria digitata extract on selected bacterial groups in the piglet gastrointestinal tract (GIT) microbiota.

Murphya P, Bello FD, O’Doherty J, Arendt EK, Sweeney T, Coffey A.

Anaerobe. 2013 Jun;21:1-8. doi: 10.1016/j.anaerobe.2013.03.002. Epub 2013 Mar 29.

PMID:23542115[PubMed – in process] Related citations

Select item 234091963.DNA-fragments are transcytosed across CaCo-2 cells by adsorptive endocytosis and vesicular mediated transport.

Johannessen LE, Spilsberg B, Wiik-Nielsen CR, Kristoffersen AB, Holst-Jensen A, Berdal KG.

PLoS One. 2013;8(2):e56671. doi: 10.1371/journal.pone.0056671. Epub 2013 Feb 11.

PMID:23409196[PubMed – in process] Free PMC ArticleRelated citations

Select item 233652744.The microbiological and immunomodulatory effects of spray-dried versus wet dietary supplementation of seaweed extract in the pig gastrointestinal tract.

Mukhopadhya A, O’Doherty JV, Smith A, Bahar B, Sweeney T.

J Anim Sci. 2012 Dec;90 Suppl 4:28-30. doi: 10.2527/jas.53875.

PMID:23365274[PubMed – in process] Related citations

Select item 230220145.Low molecular weight fucoidan ameliorating the chronic cisplatin-induced delayed gastrointestinalmotility in rats.

Song MY, Ku SK, Kim HJ, Han JS.

Food Chem Toxicol. 2012 Dec;50(12):4468-78. doi: 10.1016/j.fct.2012.09.020. Epub 2012 Sep 25.

PMID:23022014[PubMed – indexed for MEDLINE] Related citations

Select item 226325676.Effect of intraperitoneal PERIDAN™ concentrate adhesion reduction device on clinical findings, infection, and tissue healing in an adult horse jejunojejunostomy model.

Morello S, Southwood LL, Engiles J, Slack J, Crack A, Springate CM.

Vet Surg. 2012 Jul;41(5):568-81. doi: 10.1111/j.1532-950X.2012.00951.x. Epub 2012 May 25.

PMID:22632567[PubMed – indexed for MEDLINE] Related citations

Select item 219486117.Effect of maternal seaweed extract supplementation on suckling piglet growth, humoral immunity, selected microflora, and immune response after an ex vivo lipopolysaccharide challenge.

Leonard SG, Sweeney T, Bahar B, O’Doherty JV.

J Anim Sci. 2012 Feb;90(2):505-14. doi: 10.2527/jas.2010-3243. Epub 2011 Sep 23.

PMID:21948611[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 210889298.Effect of heparin, fucoidan and other polysaccharides on adhesion of enterohepatic helicobacter species to murine macrophages.

Lutay N, Nilsson I, Wadström T, Ljungh A.

Appl Biochem Biotechnol. 2011 May;164(1):1-9. doi: 10.1007/s12010-010-9109-7. Epub 2010 Nov 19.

PMID:21088929[PubMed – indexed for MEDLINE] Related citations

Select item 210840639.Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats.

Raghavendran HR, Srinivasan P, Rekha S.

Int Immunopharmacol. 2011 Feb;11(2):157-63. doi: 10.1016/j.intimp.2010.11.002. Epub 2010 Nov 26.

PMID:21084063[PubMed – indexed for MEDLINE] Related citations

Select item 2087519110.Effect of dietary seaweed extracts and fish oil supplementation in sows on performance, intestinal microflora, intestinal morphology, volatile fatty acid concentrations and immune status of weaned pigs.

Leonard SG, Sweeney T, Bahar B, Lynch BP, O’Doherty JV.

Br J Nutr. 2011 Feb;105(4):549-60. doi: 10.1017/S0007114510003739. Epub 2010 Sep 28.

PMID:20875191[PubMed – indexed for MEDLINE] Related citations

Select item 2063868911.Fucoidan film safely inhibits surgical adhesions in a rat model.

Cashman JD, Kennah E, Shuto A, Winternitz C, Springate CM.

J Surg Res. 2011 Dec;171(2):495-503. doi: 10.1016/j.jss.2010.04.043. Epub 2010 May 21.

PMID:20638689[PubMed – indexed for MEDLINE] Related citations

Select item 2035506412.The effect of dietary Laminaria-derived laminarin and fucoidan on nutrient digestibility, nitrogen utilisation, intestinal microflora and volatile fatty acid concentration in pigs.

Lynch MB, Sweeney T, Callan JJ, O’Sullivan JT, O’Doherty JV.

J Sci Food Agric. 2010 Feb;90(3):430-7. doi: 10.1002/jsfa.3834.

PMID:20355064[PubMed – indexed for MEDLINE] Related citations

Select item 1980916413.Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in in vitro gut inflammation.

Mizuno M, Nishitani Y, Hashimoto T, Kanazawa K.

Biosci Biotechnol Biochem. 2009 Oct;73(10):2324-5. Epub 2009 Oct 7.

PMID:19809164[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1978889214.Effect of fucoidan on aspirin-induced stomach ulceration in rats.

Choi JI, Raghavendran HR, Sung NY, Kim JH, Chun BS, Ahn DH, Choi HS, Kang KW, Lee JW.

Chem Biol Interact. 2010 Jan 5;183(1):249-54. doi: 10.1016/j.cbi.2009.09.015. Epub .

PMID:19788892[PubMed – indexed for MEDLINE] Related citations

Select item 1807961315.Effect of dietary fiber in edible seaweeds on the development of D-galactosamine-induced hepatopathy in rats.

Kawano N, Egashira Y, Sanada H.

J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):446-50.

PMID:18079613[PubMed – indexed for MEDLINE] Free ArticleRelated citations

Select item 1780596816.Fucoidin prevents Clostridium difficile toxin-A-induced ileal enteritis in mice.

Barreto AR, Cavalcante IC, Castro MV, Junqueira AF, Vale MR, Ribeiro RA, Souza MH, Brito GA.

Dig Dis Sci. 2008 Apr;53(4):990-6. Epub 2007 Sep 1.

PMID:17805968[PubMed – indexed for MEDLINE] Related citations

Select item 1767351117.The binding of human betacellulin to heparin, heparan sulfate and related polysaccharides.

Mummery RS, Mulloy B, Rider CC.

Glycobiology. 2007 Oct;17(10):1094-103. Epub 2007 Aug 2.

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Select item 1715732318.The suppressive effect of Mekabu fucoidan on an attachment of Cryptosporidium parvum oocysts to the intestinal epithelial cells in neonatal mice.

Maruyama H, Tanaka M, Hashimoto M, Inoue M, Sasahara T.

Life Sci. 2007 Jan 30;80(8):775-81. Epub 2006 Nov 16.

PMID:17157323[PubMed – indexed for MEDLINE] Related citations

Select item 1514734419.Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells.

Matsumoto S, Nagaoka M, Hara T, Kimura-Takagi I, Mistuyama K, Ueyama S.

Clin Exp Immunol. 2004 Jun;136(3):432-9.

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Select item 1285787020.Lectin-like Ox-LDL receptor is expressed in human INT-407 intestinal cells: involvement in the transcytosis of pancreatic bile salt-dependent lipase.

Bruneau N, Richard S, Silvy F, Verine A, Lombardo D.

Mol Biol Cell. 2003 Jul;14(7):2861-75. Epub 2003 Apr 4.

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